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Therefore, advancing from non-specific epigenetic modifiers to isoform-selective inhibitors or locally delivered agents represents a promising translational path to harness the potential benefits of HDAC modulation for tinnitus treatment while mitigating the risks associated with systemic, broad-action compounds
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dracunculus in the treatment of MS and showed that oral administration of the extract to animal models of MS, such as EAE, modulates immune responses, increases the antioxidants serum levels, and significantly reduces IL-17A and IL-23 synthesis in spleen mononuclear cells, and decreases infiltration of the immune cells and demyelination in the EAE mice brain, leading a reduction of severity of neurological deficits and clinical scores and an increase in body weight, suggesting that the compounds, contained in A
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