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These findings suggest that loss of PDI functional activity can directly lead to apoptosis, or indirectly, to a range of cellular abnormalities, such as oxidative stress, protein misfolding, as well as cell death (Jeon et al., 2014)

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Phosphodiesterase inhibitors (PDE-Is) Phosphodiesterases (PDEs) regulate the concentration of cyclic adenosine monophosphate (cAMP), a key second messenger in both eukaryotic and prokaryotic systems [106]

Malki K, et al