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Ito et al., 2023) (this may be particularly relevant for the destabilization of myelin), synaptic dysfunction (Tu et al., 2014) (this includes impairment of signaling at the axo-myelinic synapse, crucial for survival of the myelinated axon
However, these agents often lack selectivity, potentially causing unnecessary damage and apoptosis in normal cells (Marcus et al., 2018
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It's a vicious cycle of pain and progressive breakdown
Reporting of prescribing and preparation errors were also higher for compounded medications, the paper found