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"The Role of Early Biologic Therapy in Inflammatory Bowel Disease." Inflammatory bowel diseases , 25(12), (2019) 1896-1905

Previous studies have demonstrated that the use of RXR partial agonists can reduce eosinophilic airway inflammation, a condition mediated, in part, by the chemoattractant activity of CCL11 60

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Animal evidence is much larger and has been the basis for almost all of the published mechanism work

8 Ex vivo studies further confirmed GAPs efficacy in reducing oxidative deoxyribonucleic acid (DNA) lesions and cyclobutene pyrimidine dimers under UVA and UVB irradiation, respectively, though these findings were limited by the small number of biomarkers evaluated