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(PubMed) Yang SJ, Hwang SY, Choi HY, et al

Gastrointestinal effects lead: nausea, diarrhea, constipation, and vomiting, dose-dependent and clustered during escalation, mostly mild. Tirzepatide also produces a modest chronic heart-rate rise with a larger escalation-phase peak. Oral-contraceptive absorption can fall after starting and after each increase, so use backup or non-oral contraception for 4 weeks each time. What is known about concurrent metformin and tirzepatide use

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Retrieved July 23, 2026 from www.sciencedaily.com

The loss of sebum and sebaceous gland-derived products would also lead to a decrease in antimicrobial peptides typically found in sebum