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Additional functional biomarkers such as GPX activity and SelPs levels are also used to evaluate Se-dependent enzymatic functions [2]

Furthermore, the agonists of Nrf2, which serve as pivotal upstream regulators of SLC7A11, function as indirect activators of System Xc-, as they regulate SLC7A11 at the transcriptional level rather than directly modifying the functional activity of the complex (139)

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SOD is located in the cytoplasm and is considered one of the most effective enzymes