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It does not make the physician's step optional

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"Muscle as a paracrine and endocrine organ." Current Opinion in Pharmacology 34 (2017): 49-55

[2] [16] Dietary deficiency without neurological features: Initial loading doses followed by maintenance therapy, with consideration of oral supplementation in appropriate cases

Patients should be offered this alternative after an informed discussion on the advantages and disadvantages of both treatment options

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