surgeon general report on tobacco THIS DAY: 60 years ago, the issued a landmark warning urging Americans not to smoke. Read more: https://abcnews.visitlink.me/LADvOs Surgeon General's Report Shows Progress

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Whereas we operationalized chronic effects as structural alterations identified in smoker versus nonsmoker (i.e., between-subjects) comparisons, we operationalized the acute effects of nicotinic acetylcholine receptor (nAChR) agonist administration as functional alterations indentified in pharmacological neuroimaging studies, the vast majority of which employed within-subjects (i.e., drug versus control condition) comparisons