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In addition, it can effectively reduce the intestinal mucosas permeability and the intestinal endotoxin level, restoring the mechanical damage of the intestinal barrier and thus reducing intestinal bacterias translocation [145]

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16 Furthermore, elevated levels of soluble UA can initiate the activation of the nucleotide-binding oligomerization domain (NOD)-, Leucine-rich repeat (LRR)- and pyrin domain-containing protein 3 inflammasome, 17 leading to endothelial cell pyroptosis, a process modulated by cellular levels of reactive oxidative species

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