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norepinephrine increases both total peripheral resistance, as well as systolic and diastolic blood pressure Note : Compensatory vagal reflexes tend to overcome the direct positive chronotropic effects on the heart (since both branches of the ANS innervate the SA node), but do not eliminate the positive inotropic effects on the ventricle (which does not have significant vagal innervation)

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Vaping products are tightly regulated in the UK to ensure safety and quality for consumers by the Tobacco and Related Products Regulations (TRPR) and the Tobacco Products Directive (TPD)