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These sleep architecture effects position DSIP as an important research compound for investigating natural sleep regulation mechanisms, developing non-addictive sleep aids, and understanding the neurochemical basis of restorative sleep physiology

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Subsequent investigations indicated that MSU crystals targeted the NLRP3 inflammasome by suppressing macrophage miR-223 expression and facilitated the production of inflammatory cytokines, IL-1 and TNF- (43)

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