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it manifests as a spectrum of clinical conditions dominated by candidemia, and can further develop into disseminated infections involving multiple deep organs such as the kidneys, liver and heart valves, with non-specific clinical symptoms and an attributable mortality rate of approximately 30% (Pappas et al., 2018)

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Nat Rev Immunol (2011) 11:62532.10.1038/nri3042 191 Pacheco-LpezGNiemiMBKouWHrtingMFandreyJSchedlowskiM

Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes

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PubMed PMID: 20140211