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doi: 10.1128/MICROBIOLSPEC.VMBF-0016-2015 122 Muoz-BonillaA.EcheverriaC.Sonseca.ArrietaM

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This inhibition preserves cellular NAD+ levels by reducing their consumption, simultaneously increasing GLUT4 transporter expression and activating sirtuin 1, known as the "longevity gene." The compound exhibits high membrane permeability and selectivity without affecting related methyltransferases or NAD+ salvage pathway enzymes, creating targeted metabolic effects while maintaining cellular safety

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Table 1 : Fictitious Example (If a patient has an estriol of 2, an estrone of 2, a 16 a-OHE1 of 2, and an estradiol of 2, then the Total Estrogen Effect (TEE) would be 48 based on their relative binding affinities) **Although 16a-OHE1 is a Phase I metabolite, it is included in the calculation due to its ability to contribute to estrogen dominance

Magnesium citrate at 400600mg daily can provide temporary motility support during the recovery window without creating dependency