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These results validate the gene expression differences associated with regional emphysema severity in independent cohorts from different clinical settings and support the hypothesis that the genes whose expression is associated with regional emphysema severity reflect the activity of true disease-associated processes

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These data are supported by our identification of GHK as a compound with the potential to mimic TGF pathway activity and induce collagen contraction, an important functional component of wound repair

Ryter SW, Kim HP, Hoetzel A, Park JW, Nakahira K, Wang X et al

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