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During the iron cycling process, NTBI and certain unstable ferrous species are prone to oxidation and reduction through Fenton and Haber-Weiss reactions, generating hydroxyl radicals (OH)

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Monitor patients receiving Hydrocodone Bitartrate and Acetaminophen Tablets and any Cytochrome P450 3A4 inhibitor or inducer for signs of respiratory depression or sedation [see CLINICAL PHARMACOLOGY, WARNINGS, PRECAUTIONS

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