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OTA has complex mechanisms of action that include oxidative stress, bio-energetic compromise, mitochondrial impairment, inhibition of protein synthesis, production of DNA single strand breaks and formation of OTA-DNA adducts

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23 78c is a highly specific CD38 inhibitor, which has greater potency than the flavonoids in reversing NAD + decline during aging, thereby improving several age-associated physiological functions, including cardiac function, muscle function and glucose tolerance

doi: 10.1111/j.1753-4887.2010.00287.x 129

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