[1] Cell Line:PBMC, MOLM-16, SU-DHL-1 and Pfeiffer Concentration:0.1 nM, 0.5 nM, 2.5 nM, 13 nM, 64 nM, 320 nM, 1600 nM, 8000 nM, 40000 nM Incubation Time:20 h Result:Reduced the levels of STAT3 protein in human PBMCs and SU-DHL-1 cell line, with DC of 0.1 nM and 10 nM, respectively
465,466 This activation is predominantly mediated through the disruption of the Kelch-like ECH-associated protein 1 (KEAP1) - NRF2 interaction (oxidation of KEAP1 Cys151, Cys273, and Cys288), 29 facilitating the translocation of NRF2 into the nucleus
Yuan X, Wang J, Yang S, Gao M, Cao L, Li X, Hong D, Tian S, Sun C
Consistent with these observations, cold exposure has been shown to disrupt cytoskeletal remodeling in neurons (22)
Aim for variety and a minimum of four to five servings per day
room temperature for 1 h under shaking