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Recent advancements reveal a critical role of lipid metabolism dysregulation in the pathogenesis and severity of depressive disorders

For instance, organoid models have clearly shown that phytoestrogens and polyphenols can regulate ER/ER signalling and aromatase activity within breast tissue-like architecture (221), whereas immune cell co-cultures have demonstrated that -glucans, mushroom polysaccharides, as well as selected probiotics can increase NK cytotoxicity and DC maturation thereby providing a preclinical rationale to consider integrating immunomodulatory supplements into combinatorial therapy regimens (221)

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Mass spectrometry provides the highest accuracy of direct measures of micronutrients in serum and within cells