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Because the final inflated average case-weighted standardized charge per case exceeded the average case-weighted threshold amount, the applicant asserted that the TOPS TM System meets the cost criterion

No serious TEAEs, TEAEs leading to study withdrawal or deaths were reported

However, like any medical treatment, they should be approached with informed consideration and professional guidance

It is also worth noting that Mn 2+ was reported to directly promote antitumor immune responses by activating cGAS-STING 36,66

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