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To study their role in ferroptosis in ER+ breast cancer models, we depleted AGPAT3 and FAR1 using siRNA SMARTpools or a CRISPR sgRNA approach and treated MCF-7 and T47D cells with palbocicilib, RSL3, or the combination in clonogenic assays (Fig

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Because glutathione operates at the foundational, cellular level, its depletionand subsequent restorationcan impact a wide array of multi-system symptoms

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Hope that helps a little