While many associate B12 deficiency with poor nutrition, a significant number of cases are due to non-dietary causes, such as Pernicious Anaemia
By blocking NNMT, it prevents the methylation reaction that depletes SAM and nicotinamide, thereby preserving both cofactors and restoring the metabolic machinery that NNMT overexpression had suppressed
When They Should Not Be First-Line Therapy Despite their efficacy, novel weight loss peptides should generally not replace GLP-1 or GIP receptor agonists as initial therapy for uncomplicated obesity
It is important to note that B12 levels should ideally be measured before commencing replacement therapy, as supplementation rapidly normalises biochemical markers, potentially obscuring the diagnosis
10.1007/s10930-022-10074-5 13 HepsomaliP.GroegerJ
Another gene of particular interest is ALDH2, which encodes aldehyde dehydrogenase 2, a key enzyme involved in alcohol metabolism [51]