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The critical limitation for both compounds is the same: evidence is preclinical, human clinical data is either minimal (BPC-157) or nonexistent (KPV), and both are sourced through unregulated markets where product quality cannot be guaranteed

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It simply receives fewer signals to do so

Additionally, chemoaffinity protocols such as immobilized metal affinity chromatography (IMAC) or titanium dioxide (TiO 2 ), although widely used in phosphoproteomics, lack site selectivity for phosphorylation at serine (pS), threonine (pT) or tyrosine (pY) 8,9 and exhibit a sequence bias in favor of peptides rich in aspartic (D) and glutamic (E) acid

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PMID: 39198677 Sci RepMachine learning-based screening and validation of liver metastasis-specific genes in colorectal cancer