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By using liposomal delivery, we address the two main hurdles of absorption: stability and transport

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Aksoy S, Szumlanski CL, Weinshilboum RM

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Similarly, a single intracerebral injection of CRISPR-LNPs targeting PLK1 (sgPLK1-cLNP) enabled in vivo editing of 70% of genes in aggressive orthotopic glioblastoma cells, induced tumor cell apoptosis, inhibited tumor growth by 50%, and increased survival by 30% [293]

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