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The peptide increases the synthesis of collagen types I and III, the main structural proteins in connective tissue

Acute caffeine administration preferentially antagonizes A 1 receptors, whereas repeated exposure primarily inhibits A 2A receptor signaling, resulting in distinct adaptive mechanisms [12, 69, 70]

J Neurosci 40(45):8604-8617

DOI: Received: Accepted: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-031-19369-9 Online ISBN: 978-3-031-19369-9 eBook Packages: Living Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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Previous research demonstrated that furosemide, an anthranilate-based medication, can downregulate the proinflammatory microglial M1 phenotype