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However, this large number warrants important context: 35 of the 36 studies included in the systematic review were preclinical (conducted in laboratory or animal models), and only one clinical study met the review's inclusion criteria

Laboratory abnormalities, dyspnea, dry eyes, and cardiovascular side effects were reported in 0.2% (1/389) of patients

Dose: Many clinical studies have used 250500 mg/day , with some trials using up to 1,000 mg/day

506 , 523 , 717 , 718 , 719 , 720 , 721 , 722 , 723 , 724 , 725 , 726 , 727 , 728 Additional research on interventions focused on disease stages is also required, as is research on specific intervention needs for LGBTQIA+ caregivers for whom a lack of inclusive practices on the part of health care professionals, stigma and a reluctance to seek support may result in greater unmet needs compared with nonLGBTQIA+ dementia caregivers

Warning signs to watch for include: Severe allergic reactions Swelling of the face, lips, or throat, hives, or difficulty breathing may signal anaphylaxis, a medical emergency