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Among the various regulatory factors, peroxisome proliferator-activated receptor (PPAR) coactivator 1 (PCG-1), the master regulator of mitochondrial biogenesis, emerges as an important component involved in the defective mitochondrial biogenesis in CKD ( Consistent with the crucial function of PGC-1 in mitochondrial biogenesis, the down-regulation of PGC-1 levels is prevalent in animal models of CKD and also in patients with CKD

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