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This work was partly supported by grants from the Uehara Memorial Foundation and Takeda Science Foundation

Research shows low-load BFR training can drive tendon adaptations comparable to high-load training: 14 weeks ~8% cross-sectional area & ~36% stiffness (Centner et al., 2019) Short-term pain relief (~45 min) enabling loading when it otherwise hurts (Korakakis et al., 2018) This means athletes and patients can achieve meaningful tendon stimulus and pain relief without high mechanical stress

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3b) showed severe histopathological changes which are consistent with cardiotoxicity manifested as scattered chronic inflammatory cells with focal fragmentation of myocardial fibers and loss of nuclei (arrowhead)