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It should also be noted that before approving our protocols, the IRB engaged a second external expert who did not share the concerns regarding clinical equipoise

Strategies for coping Until the tear can be treated arthroscopically, patients with a torn meniscus can use non-narcotic pain relievers, and should try to do quadriceps muscle contractions to prevent atrophy that is associated with knee pain and swelling.One may also need to modify activities to avoid those that twist the knee

While Warning Letters are not uncommon in the pharmaceutical industry, this case stands out because it goes far beyond isolated documentation issues

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