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Finally, low glutamine in the core region of solid tumors led to histone hypermethylation due to decreased -ketoglutarate level, resulting in cell dedifferentiation and therapeutic resistance in melanoma cells [64]

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Its shorter duration of action more closely mimics the pulsatile nature of endogenous GHRH secretion, thereby supporting physiological episodic GH release patterns in contrast to CJC-1295 with DAC, which produces sustained GH elevation with days-long GHRH-receptor occupancy

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10.3389/fphar.2025.1570385 4 AliM