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2011 Mar 14;88(11-12):535-42

Results in rodent models have shown that exposure to LAN accelerates mammary tumor development, increases estrogenic activity, and reduces circulating melatonin levels 159

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These transmembrane enzymes utilize NADPH to reduce O 2 , directly producing H 2 O 2 (as by NOX4, DUOX1/2) [72] or indirectly via O 2 generation (by NOX1-3) [73], which rapidly dismutates to H 2 O 2