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Mechanistically, these effects are linked with the inhibition of pro-inflammatory protein production in response to LPS-stimulated cells, preventing necrosis in the LPS-affected cells (Tan et al., 2022)
Research links its activity to improved mitochondrial respiration, energy output, and reduced apoptotic signaling under metabolic stress, making it essential in studies of cellular energy preservation
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Science & studies 4.1 Key publications Before going into the details of the individual studies, here are 6 key publications on which the BPC-157 evidence base rests: Sikiric P., Seiwerth S., Rucman R., et al
Ingram DK, Zhu M, Mamczarz J, Zou S, Lane MA, Roth GS, DeCabo R (2006) Calorie restriction mimetics: an emerging research field