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These results were corroborated and deepened by Marcello et al

12 In addition, Asp can promote the activation of hypoxia-inducible factor HIF-1 and inflammasome in M1 macrophages and increase the production of Asn and other metabolites

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Further research of in vivo and in vitro treated hepatocytes and liver fractions would complement our findings

Fleischer M, Szepanowski RD, Pesara V, Bihorac JS, Oehler B, Dobrev D, et al

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