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Diabetes Care 35, 226232

(2020) specifically addressed NSAID-induced gut damage a clinically relevant injury model and documented that BPC-157 administration stabilized the claudin-4 and occludin tight junction proteins that are degraded by NSAID exposure, providing a mechanistic explanation for the peptides permeability-protective effects

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This observed delay is likely multifactorial

We start with the dominant symptom, monitor response, and add therapies in a staged fashion, always weighing metabolic and oncologic risks