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Linus Pauling Institute Oregon State University Updated in March 2003 by: Jane Higdon, Ph.D

What follows is what we know from that review and from the published clinical record

Are they safe

What the trials measured and when The METAOD005 oral trial measured weight at 12 weeks

Why Medical Supervision Matters The wellness industry is full of bold claims, but real progress usually comes from individualized care

The FDA label includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, contraindicating use in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2