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At the same time, there are paradoxes: small dogs often produce more ROS yet still accumulate fewer pathologies, while wild canids of comparable size live longer than domestic breeds, suggesting that selective breeding has altered antioxidant capacity

10.1016/j.cell.2018.07.019 141 LeoneR

Oxidative stress markers, including MDA, were significantly elevated and correlated with reduced synthesis of GSH, the most important skin antioxidant (164)

ANS-DOX showed to be toxic in GSTA1-1 overexpressing cancer cells

Once dissolved in water, even synthetic betaine HCl is indistinguishable from regular betaine under the same pH because they are actually the "acid" and "base" forms of the same molecule