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Given the data Ive shown that it should not cross the cell membrane

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J Orthop Surg Res

His6- and GST-tagged protein samples were cleaved using TEV protease, followed by repeated purification on an Ni-NTA column

This is the most common question and the answer from a mechanistic standpoint is yes, they are complementary rather than redundant : BPC-157 works through nitric oxide and growth factors (gut-mediated) TB-500 works through actin mobilization and cell migration (structural) These are non-overlapping pathways, which is the theoretical basis for combining them

1 2 "Advances in the understanding of cobalamin assimilation and metabolism"