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While internal Nm modifications have been associated with the enhanced stability of specific transcripts, such as Pxdn mRNA, the precise molecular mechanisms remain to be fully elucidated [128]

Fibroblasts play an important role in turnover of extracellular matrix

In health cells, cytosolic NADH is shuttled into mitochondria, where it is turned into NAD + by OXPHOS whereas in cancer cells, the conversion of NAD + to NADH in mitochondria is not sufficient for the high rate of glycolysis due to reduced OXPHOS