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However, its use was associated with an increased risk of infections and cancer, similar to other biologics, as well as an increase in all cause mortality in patients 50 years and older with at least one CV risk factor (Lee et al, 2014

To further prolong the shelf life of the peptides storing in a refrigerator between 2C and 8C is recommended

doi: 10.1021/acs.jafc.1c01382 58 XuT

10.1161/circresaha.115.307611 57 HongY.FengJ.DouZ.SunX.HuY.ChenZ.et al (2024)

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Additionally, the ncAA incorporation sites must be selected carefully, as the inappropriate incorporation could impact the antibody stability and binding affinity