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In an important study by Khokhar and Tyndale, the authors found that 7 days of nicotine treatment increased CYP2B expression in the brain, but not liver, and surprisingly, this change in metabolism was sufficient to potentiate the sleep-inducing effects of the general anesthetic propofol in male rats (167)

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Fifteen percent of the funds would be used to carry out brain research in California on the causes, early detection, treatment, prevention, and cessation of the use of cigarettes, other tobacco products, and other addictive substances and behaviors

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