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The success of this approach in modulating both energy metabolism and epigenetic regulation suggests that other metabolic nodes may offer similar opportunities for dual-pathway intervention

Sequence (Amino Acid): Ala-His-Lys (AHK)

The compound's unique mechanism of action simultaneously preserving NAD+ availability and methylation capacity through selective NNMT inhibition offers researchers a powerful approach to investigating metabolic flexibility and cellular adaptation

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

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