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10.1111/febs.13820 FEBS J

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Several other studies (one of them being a large scale community-based Framingham Heart Study [221]) have suggested a role for IGF-1 in the prevalence of insulin resistance and MetS [221223]

If applied locally via injection, as was done in the study, there is also a risk of structural damage as the needle could break the fragile external walls that protect the discs

This included a reduction in inflammatory cytokines, accelerated migration of corneal keratinocytes, and restoration of the epithelial barrier