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Zhang et al., 2024b)

Limited Human Reports A small number of human publications exist, but their scale and design do not establish general safety or effectiveness

Indeed, compared to the sham group, LOsG significantly decreased both FoxO1 mRNA and protein expression, as demonstrated by immunohistochemistry analysis (Fig

Additionally, certain protein post-translational modification pathways, including aberrant ubiquitination, phosphorylation, methylation, and glycolysis, are associated with dysregulated immune responses and inflammation in IBD [331]

CSF provides buoyancy and protects the brain from external forces, allowing the brain to bounce away from the skull when hit in the head, thus behaving like a shock absorber, but when this shock exceeds the threshold, as in the case of TBI, the levels of inflammatory proteins, like IL-6, IL-8 and IL-10 increase in the CSF [90]

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