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As of April 2026, the following clinical realities must be noted: Limited Human Trials: While Phase 1/2 exploratory studies have investigated peptide safety and local administration (e.g., intra-articular for osteoarthritis), large-scale Randomized Controlled Trials (RCTs) confirming systemic efficacy in humans are absent (Dove Medical Press, 2025)

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By inducing the expression and activity of HO-1, it can enhance the antioxidant, anti-inflammatory, and anti-apoptotic capacity of tissues, and thus reduce the degree of damage in diabetic complications

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TB-500 is more commonly seen in clinical practice with injury rehabilitation protocols