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It acts as a modulator, increasing NO when it is too low (causing poor blood flow) and decreasing it when it is too high (causing oxidative stress)

doi: 10.3109/10799893.2015.1030412 39 FilardoEJQuinnJABlandKIFrackeltonAR

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Clinical Trial Findings Oral Bioavailability Challenge: Randomized controlled trials (RCTs) on standard oral GSH supplementation show mixed and controversial results

While we cant yet prescribe specific bacterial cocktails for B12 optimization, understanding this connection helps explain why some people need way higher doses despite similar starting points