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Parkinsons Disease (PD) Neuronal loss in the substantia nigra (SN) is a neuropathological characteristic of PD, which leads to striatal dopaminergic insufficiency and an increase in the synthesis of -synuclein in neuronal inclusions [176]

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However, NAC has been shown to restore GSH levels in cases such as acetaminophen (paracetamol) overdose, where an acute depletion of GSH is observed [17]

This ultimately leads to an elevated CD4+/CD8+ ratio [56]

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It affects both a persons mood and their ability to function and is associated with increased risk of suicide (Cavanagh et al