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Intestinal tissues of IBD patients show elevated Th17 cells and pro-inflammatory factors (IL-17A, IL-17F, IL-23), contributing to intestinal inflammation (180182)

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the ratio between GSH and GSSG is held in dynamic balance depending on many factors including the tissue of interest, intracellular demand for conjugation reactions, intracellular demand for reducing power, extracellular demand for reducing potential, and the complex interplay between several regulatory enzymes including glutathione peroxidase (GPx), glutathione- S -transferase (GST) and -glutamyltransferase (GGT)

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Activating both at the same time produces a substantially larger pulse more than the sum of the two individual effects

It was a nontrivial task to review a manuscript of this size and they were both constructive and rigorous in their work