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Thus, it is possible that the combination of low GH and normal IGF-I serves as a physiological mechanism aimed at preserving the GH/IGF-I anabolic effects and minimizing the insulin-antagonistic effects of GH without compromising the positive IGF-I metabolic effects

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Gene Control Exerted by Retinoic Acid Retinol is converted to retinaldehyde via the action of two classes of oxidizing enzymes, cytoplasmic and microsomal