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Statistical analysis All statistical analyses were conducted using Prism, version 9 (GraphPad Software Inc., San Diego, CA, USA)
Alzheimers disease (AD), the most common form of dementia worldwide 270,271 , is characterized at the molecular level by the accumulation of A plaques, tau neurofibrillary tangles (NFTs), declined NAD + levels, mitochondrial stress, and impaired mitophagy, occurring first in the medial temporal lobe and eventually spreading to temporal and parietal cortices, and cortex 112,242,243,270,271,272
Data analysis was performed using Clampfit 10.2 software (Molecular Devices), and Mini- Analysis 6.0 software (Synaptosoft Inc
Growth Hormone Therapy is used to directly replace declining levels of human growth hormone, but does not address the root cause of why human growth hormone levels are declining
Thymalin, another thymus peptide, has been studied for its potential to restore T-cell populations