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Owing to their high intracellular abundance, they also serve as indicators of compromised cellular integrity: once released extracellularly, HSP70s act as damage-associated molecular patterns (DAMPs), triggering immune responses through receptors such as the toll-like receptors TLR2 and TLR4 (Theivanthiran et al., 2022

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Both antibodies are effective in treating relapsed/refractory MM and can be used in combination with other therapies 148,149