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Inhibition of TGR was shown in biochemical assays with recombinant protein, and in ex vivo worms by measurement of both TGR-generated fluorescent products from TRFS-Green and the decrease in the GSH/GSSG ratio

The OxD of the cytosolic Grx1roGFP2 sensor at steady state was 0.120.01, that is, 12% of the pool of sensor molecules was in an oxidized state (Figure 1C)

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Glaucoma patient with 80% ganglion cells remaining shows greater neuroprotective response than patient with 10% remaining

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